The Ontogeny of Primitive and Definitive Hematopoietic Cells
نویسنده
چکیده
T HE MYSTERIOUS GENESIS of hematopoietic stem cells during early vertebrate development has intrigued investigators for several centuries. The molecular steps that lead to embryonic hematopoiesis remain to be determined, although recent studies have begun to define early events and migration patterns that regulate the hematopoietic program. This review will provide a historical background of the developmental biology of vertebrate hematopoiesis and highlight the systems and methods that are being used to study the regulation of the hematopoietic stem cell during embryogenesis.
منابع مشابه
Ontogeny of erythropoiesis.
PURPOSE OF REVIEW The present study review examines the current understanding of the ontogeny of erythropoiesis with a focus on the emergence of the embryonic (primitive) erythroid lineage and on the similarities and differences between the primitive and the fetal/adult (definitive) forms of erythroid cell maturation. RECENT FINDINGS Primitive erythroid precursors in the mouse embryo and cult...
متن کاملThe Ontogeny of Primitive and Definitive Hematopoietic Cells
T HE MYSTERIOUS GENESIS of hematopoietic stem cells during early vertebrate development has intrigued investigators for several centuries. The molecular steps that lead to embryonic hematopoiesis remain to be determined, although recent studies have begun to define early events and migration patterns that regulate the hematopoietic program. This review will provide a historical background of th...
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